2021 Mercedes-Benz S-Class Common Problems & Defect Telemetry
Authoritative defect intelligence synthesized from 34 verified NHTSA owner complaints, 0 federal safety recalls, and interquartile failure mileage telemetry.
The 2021 Mercedes-Benz S-Class receives a 8/10 MazicBay Reliability Index based on 34 verified NHTSA federal complaints and 0 safety recalls. The primary reported failure mode is Electrical Parasitic Drain, Infotainment & Harness Reports with a median failure point at 55,000 miles (IQR: 35,000 – 75,000 mi). Out-of-warranty repairs benchmark at $280 – $850 .
7.6 complaints / 10k sold
Verified US federal records
Crash, fire & stall audit
0 Active / Free Remedies
Top Reported Problem Clusters (7)
Electrical Parasitic Drain, Infotainment & Harness Reports
- Unexplained battery drain after sitting overnight
- Infotainment display / instrument cluster blackouts
- Accessory malfunction / alternator fault warnings
“False warning message for right taillights/brake lights/signal light in rear lamp.”
“The contact owns a 2021 Mercedes-Benz S580. The contact stated that while driving at various speeds, the "Camera System Unavailable" and "Camera Dirty" messages were displayed on the instrument panel. The vehicle was initially taken to a dealer where the contact was informed t...”
“Similar to recall campagn #2017020018 or 17V-078. My car may have a damaged steering column-mounted shift lever module. If the internal circuit board is damaged, moving the shift lever will not select a transmission gear. Both the auto-P function and automatic parking brake wi...”
Engine Stalling, Oil Consumption & Cooling Defect Reports
- Engine sudden stall / hesitation while driving
- Abnormal oil burning / consumption
- Check Engine Light (MIL) flashing
- Engine overheating / coolant loss
“The vehicle lost acceleration and the check engine light came on. I took the vehicle to Mercedes dealership. They quoted that the Camtronic actuator has failed and needs to be replaced. Cost $9000. I have now seen online a recall for 2021 mercedes s580's for CAMTRONIC actuator...”
“The contact owns a 2021 Mercedes-Benz S580. The contact received notification of NHTSA Campaign Number: 24V704000 (ENGINE AND ENGINE COOLING); however, the part to do the recall repair was unavailable. The contact stated that the manufacturer had exceeded a reasonable amount o...”
“The contact owns a 2021 Mercedes-Benz. The contact stated while driving at 10 MPH, the vehicle stalls until the contact engages the vehicle in sport mode. The vehicle was not taken to an independent mechanic or dealer for diagnosis or repairs. The manufacturer was not notified...”
Electric Power Steering Assist & Suspension Noise Reports
- Sudden loss of electric power steering assist
- Steering wheel pull or highway wander
- Clunking / knocking noise over bumps
“Shock air leaking front right side. The car has 31,000 miles and is 5 years old. Is this to be expected?”
“Three wheels had rim a total of eight cracks that lead to one tire unable to hold air. Loss of air in tire can lead to crash. Mercedes service inspected car after first crack was noticed by Discount Tire when they diagnosed deflation in tire. Mercedes service reported that two...”
“Excessive Tire failure on "AMG" 21 inch wheel and tires. Pirelli tires have replaced 4 tires in four months. cracks in side wall bubbling.”
Service Brakes, ABS Actuator & Master Cylinder Reports
- Spongy or hard brake pedal travel
- ABS / Brake warning light illuminated
- Extended stopping distance / pedal vibration
“False warning message for right taillights/brake lights/signal light in rear lamp.”
“The contact owns a 2021 Mercedes-Benz S580. The contact stated that while driving at 50 MPH and attempting to accelerate, the vehicle inadvertently activated the Forward Collision Avoidance feature and briefly applied the brakes hard enough for the ABS to be activated. The con...”
“Similar to recall campagn #2017020018 or 17V-078. My car may have a damaged steering column-mounted shift lever module. If the internal circuit board is damaged, moving the shift lever will not select a transmission gear. Both the auto-P function and automatic parking brake wi...”
Transmission Hesitation, Hard Shifting & Slipping Reports
- Hard gear shifts / delayed engagement into Drive/Reverse
- Transmission shudder / jerking under acceleration
- Transmission slipping between gears
“Similar to recall campagn #2017020018 or 17V-078. My car may have a damaged steering column-mounted shift lever module. If the internal circuit board is damaged, moving the shift lever will not select a transmission gear. Both the auto-P function and automatic parking brake wi...”
“Issue: STARTER BATTERY Repetitive online and dashboard screen message notices stating, "BATTERY CHARGE Status Critical," at all hours of day and night requesting immediate 30-60-min. of driving or car will not start. Have had to wake up from nightime sleep to drive car in midd...”
“The contact owns a 2021 Mercedes-Benz S580. The contact stated while driving at 60 MPH, the contact pressed a button on the steering wheel to engage the cruise control function on the vehicle. The contact stated when driving past a mileage sign stating 40 MPH, the vehicle sudd...”
Airbag Occupant Detection & Inflator Defect Reports
- SRS Airbag warning lamp illuminated
- Passenger occupant classification sensor failure
- Seat belt retractor lockup
“Background: This is a V-8, gas vehicle.The 12-volt battery gives CRITICAL CHARGE notifications constantly. Incident: Dry pavement, 400-mile, January winter night, highway driving in Wisconsin Northwoods at posted 70 mph; some with cruise control, some without cruise control. S...”
“The contact owns a 2021 Mercedes-Benz S580. The contact stated while driving at 60 MPH, the contact pressed a button on the steering wheel to engage the cruise control function on the vehicle. The contact stated when driving past a mileage sign stating 40 MPH, the vehicle sudd...”
Fuel Pump Pressure Loss & Fuel Delivery Defect Reports
- Sudden loss of propulsion power at highway speeds
- Extended engine cranking / failure to restart
- Fuel odor near fuel tank / engine bay
“The contact owns a 2021 Mercedes-Benz S580. The contact received notification of NHTSA Campaign Number: 23V445000 (Fuel System, Gasoline) however, the part to do the recall repair was unavailable. The contact stated that the manufacturer had exceeded a reasonable amount of tim...”
Pre-Purchase Inspection Checklist for 2021 Mercedes-Benz S-Class
Before purchasing a used 2021 Mercedes-Benz S-Class, perform the following targeted inspections based on reported federal defect patterns:
Scan the OBD-II port under the dash for pending freeze-frame codes (e.g. P0300 misfires, P0087 fuel rail pressure, P0420 catalytic efficiency).
Test vehicle at low-speed stop-and-go and highway merges. Check for delayed reverse engagement or gear shift shudder between 2nd and 3rd gears.
Verify that all 0 NHTSA safety recall campaigns have been performed by an authorized dealership using the VIN.
Ensure the instrument cluster, center screen, and auxiliary charging ports operate with stable 12.0V–14.4V alternator voltage.
Defect & Reliability Q&A: 2021 Mercedes-Benz S-Class
Is the 2021 Mercedes-Benz S-Class a reliable used car?
The 2021 Mercedes-Benz S-Class earns a 8/10 MazicBay Reliability Index based on 34 federal owner reports. Vehicles maintained under factory service schedules exhibit strong longevity past 150,000 miles.
What is the most frequent defect reported on the 2021 Mercedes-Benz S-Class?
The leading complaint category is Electrical Parasitic Drain, Infotainment & Harness Reports, with a median failure point around 55,000 miles (IQR: 35,000 – 75,000 mi).
Are there free recall repairs available for the 2021 Mercedes-Benz S-Class?
Yes, the NHTSA records 0 safety recall campaign(s) for this model year. All safety recalls are performed 100% free of charge by authorized franchise dealerships regardless of vehicle warranty status.